P631: Tandem Pauson-Khand microwave reaction
The aim of this undergraduate research project was to study the Tandem Pauson-Khand reaction using microwave technology. Most research courses allow for three hours of laboratory per credit and often times the challenge is to develop a project that provides the basic research elements a student may encounter in graduate school or industry setting. By employing microwave technology, reactions that occur in hours can be reduced to minutes allowing for more experiments to be run throughout a semester. The classical thermal Pauson-Khand reaction with dicobalt octacarbonyl normally requires high temperatures and long reaction times to facilitate the intramolecular cycloaddition. Mild conditions employing N-methylmorpholine-N-oxide allows for the cyclization conditions to occur at room temperature but still require long reaction times. Through the utilization of a bench-top microwave unit, we sought to study the tandem reaction as compared to standard practices. Using this technique on milligram scale, various metals, reaction times and yield results will be illustrated.