P264: Green chemistry in a senior capstone course: Combining green chemistry, synthesis, spectroscopy, and research
This talk will discuss the design of a green synthesis for a senior capstone chemistry course. The synthesis was designed to incorporate green chemistry and research methods into a course design focusing on organic synthesis and advanced spectroscopy techniques. We designed a four-step synthesis for 3,5-diarylisoxazoles that involves a Freidel-Crafts Acylation followed by an Aldol Condensation to produce a Chalcone intermediate. The Chalcone is brominated and then converted into the diarylisoxazole. The first cohort of students performed the traditional synthesis. Undergraduate research students then redesigned the synthesis to incorporate green reagents and solvents. The redesigned green synthesis was then introduced to the second cohort of students to research the versatility of the new scheme to produce 3,5-diarylisoxazole derivatives. Undergraduate research students working to optimize the synthesis are now addressing the observations and results of the second cohort. This cycle has been extremely successful in sparking students’ interest in green chemistry and green synthesis research.